SIBUTRAMINE HCl

SIBUTRAMINE HCl

PRODUCT IDENTIFICATION

CAS NO.

106650-56-0 (Base), 84485-00-7 (HCl)

SIBUTRAMINE HCl

EINECS NO.

FORMULA

C₁₇H ₂₉Cl₂NO

MOL WT.

334.33

H.S. CODE

TOXICITY

SMILES

SYNONYMS

n,n-Dimethyl-alfa-(2-methylpropyl)-cyclobutanemethanamine 1-(4- chlorophenyl) Hydrochloride;

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

White to off-white crystalline powder

MELTING POINT

190 - 197 C

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

FLASH POINT

STABILITY

Stable under ordinary conditions

APPLICATIONS

Sibutramine is used in the management of obesity by increasing the amount of neurotransmitters serotonin and norepinephrine. Sibutramine inhibits the re-uptake of these neurotransmitters by the nerve cells and alters the balance of neurotransmitters within the nerve cells. Unlike other diet drugs (fenfluramine, dexfenfluramine) which increase release of these neurotransmitters from the cells, the action of sibutramine is similar to anti-depressants (fluoxetine) which inhibit reuptake of serotonin.

Pharmacological actions of Sibutramine

Anti-Obesity Agent
Antidepressive agent
Appetite depressant
Central Nervous System Agent
Psychotropic

Anti-obesity	CAS RN.
Amfepramone	90-84-6
Benfluorex	23602-78-0
Butenolide	497-23-4
Dapiclermin	444069-80-1
Diethylpropion hydrochloride	134-80-5
Dirlotapide	481658-94-0
Ibrolipim	133208-93-2
Metreleptin	186018-45-1
N-Methyl-beta-carboline-3-carboxamide	78538-74-6
Norpseudoephedrine	36393-56-3
Orlistat	96829-58-2
Perflubron	423-55-2
Phenmetrazine	134-49-6
Phentermine	122-09-8
Phenylpropanolamine	14838-15-4
Pyroglutamyl-histidyl-glycine	69275-10-1
Rimonabant	168273-06-1
Satietin	72026-83-6
Sibutramine hydrochloride	84485-00-7
Sibutramine	106650-56-0
Talibegron hydrochloride	178600-17-4
Taranabant	701977-09-5
Topiramate	97240-79-4
Trodusquemine	186139-09-3

SALES SPECIFICATION

APPEARANCE

White to off-white crystalline powder

ASSAY

98.5% min

HEAVY METALS

20ppm max

RESIDUE ON IGNITION

0.5% max

LOSS ON DRYING

5.0 - 7.0%

TRANSPORTATION

PACKING

HAZARD CLASS

UN NO.

PRICE INFORMATION